Inflammation, Free Radical Damage, Oxidative Stress, Hydrogen and Cancer



Musings from 20th Street

Once again, I am privileged to be able to publish one of Mark Sircus’ articles. We continue our exploration into the powerful healing effects of hydrogen. Read, and be awed by Dr. Sircus’ understanding and knowledge base, as well as his experience. Read, and be enlightened about a healing technology that is just coming into its own now that we have solid research to support it.

Come to La Casa to experience our various hydrogen therapies. Or, order hydrogen tablets for at home use at a discounted price through the code below. I would like to say here that this is the first product that La Casa has ever offered online through its Musings. That’s how much I believe in drinking H2 water.

La Casa has five different delivery systems for hydrogen:

  1. inhalation (specific for eyes, ears, brain, nose and throat)
  2. original or flavored water (most powerful systemic application)
  3. hydrogen colonic (alkalizing cleansing)
  4. nanovated hydrotherapy bath (combines smaller than nano-sized highly concentrated oxygen and hydrogen molecules)
  5. spray (anti-aging)

Soon, we will have, in addition, a hydrogen shower (as soon as the manufacturer finishes making it).

Use the “DRJANE” code for a 10% discount on Vital Reaction H2 tablets.

Inflammation, Free Radical Damage,
Oxidative Stress, Hydrogen and

by Mark Sircus

Studies on brain tumors in the past 10 or more years have shown an increase in the incidence of brain tumors in the general population. Can you guess why this is so? Extensive research during the last two decades has revealed the mechanism by which continued oxidative stress leads to chronic inflammation, which in turn mediates most chronic diseases including cancer.

Oxidative stress, caused by rivers of free radicals, is a plague on modern man. Whether it’s the toxic pollution in the air you breath 24/7, the radiation your doctor exposes you to (1), pharmaceutical medicines, chemotherapy, your cell phone constantly at your brain, or even your Wi-Fi and other EMF pollution generating devices, you expose yourself to oxidative stress (2), which will drag you down into the pit of disease and cancer, putting an end to your happiness, health and even life.

Oxidative stress has been associated with numerous health conditions including chronic fatigue syndrome, fibromyalgia, diabetes, Alzheimer’s disease, anxiety, insomnia, cancer, and just about every disease you can imagine. Yet doctors seem to ignore this fact and work as hard as they can to increase your oxidative stress, when they know we are already against the wall with toxins and stress. Imagine a patient, newly in remission from cancer, being exposed every three months to CAT or PET scans, which dramatically increase oxidative stress, just begging for the cancer to come back so they can treat it again.

Oxidative stress, directly or indirectly caused by chemotherapeutics is one of the underlying mechanisms of the toxicity of anticancer drugs in noncancerous tissues, including the heart and brain (3). During cancer chemotherapy, oxidative stress-induced lipid peroxidation generates numerous electrophilic aldehydes that attack many cellular targets (4). Oxidative stress, generated by almost all prescribed drugs as they are metabolized, acts as a source of origin and progression of many dreadful diseases. Reactive metabolites formed during this process cause oxidative stress and can impair the function of drug metabolizing enzymes leading to toxicity (5).

Pollution is a greater global threat than Ebola and HIV, according to warnings by the World Health Organisation. According to its recent report, one in four deaths among children aged under five are now due to environmental hazards such as air pollution and contaminated water. It is simple: poisons in our air and water create oxidative stress, disease, cancer and death. Epidemiological studies have shown a clear association between cardiovascular morbidity, decreased lung function, increased hospital admissions, mortality, and airborne concentrations of photochemical and particulate pollutants.

Cellular exposure to ionizing radiation leads to oxidizing events that alter atomic structure through direct interactions of radiation with target macromolecules or via products of water radiolysis. Further, the oxidative damage may spread from the targeted to neighboring, non-targeted bystander cells through redox-modulated intercellular communication mechanisms.

People who started using cell phones at an earlier age have a greater chance of developing a brain tumor when compared to people who started late (during their adult years).

When certain chemicals in the body lose an electron, they become positively charged (and are called “free radicals” or “oxidants”). These chemicals roam freely through the rest of the body stealing electrons from other cells. Free radicals damage cellular DNA. The majority of modern science has come to the conclusion that free radical damage in the human body is the cause of aging. Aging is evidence of the damage to millions of the body’s cells through oxidation. This oxidation is due to the lack of hydrogen anions that are available to stop free radical damage.

Reactive oxygen species (ROS) are a byproduct of normal metabolism. Even under pristine conditions when our cells use glucose to make energy we create a cascade of free radicals that cause oxidative stress. The more sugar we consume to greater our oxidative stress. When our immune system is fighting off bacteria and creating inflammation we suffer from increased oxidative stress. When our bodies detoxify pesticides, herbicides, fungicides and cigarette smoke we create oxidative stress.

Pancreatic cancer cells use the sugar fructose to help tumors grow more quickly. Tumor cells fed both glucose and fructose used the two sugars in two different ways, a team at the University of California Los Angeles found. Their findings, published in the journal Cancer Research, helps explain other studies that have linked fructose intake with pancreatic cancer, one of the deadliest cancer types. Researchers concluded that anyone wishing to curb their cancer risk should start by reducing the amount of sugar they eat.

Oxidation increases when we are physically and/or emotionally stressed. However, as long as we have enough anti-oxidants, a careful balance is maintained and damage is prevented. Oxidative stress happens when the amount of free radicals exceeds the amount of antioxidants. That’s when oxidation damages our cells, proteins and our DNA (genes). Oxidative stress is essentially an imbalance between the production of free radicals and the ability of the body to counteract or detoxify their harmful effects through neutralization by antioxidants.

Hydrogen as Key Antioxidant

against Oxidative Stress and Cancer

Oxidative stress is closely related to all aspects of cancer, from carcinogenesis to the tumor- bearing state, from treatment to prevention. The human body is constantly under oxidative stress arising from many sources. Active oxygen species are involved in carcinogenesis through two mechanisms: (1) the induction of gene mutations that result from cell injury and (2) the effects on signal transduction and transcription factors (6).

Molecular hydrogen (H2) functions as an extensive protector against oxidative stress, inflammation and allergic reactions.7 H2 directly reacts with the strong reactive nitrogen species peroxynitrite (ONOO-) as well as hydroxyl radicals (•OH), but not with nitric oxide radical (NO). Molecular hydrogen is a new medical gas that can be dissolved in water and administered through drinking, inhalation, baths, intravenous drip (IV), and has been shown to suppress VEGF (Vascular Endothelial Growth Factor), a key mediator of tumor angiogenesis (the development of new blood vessels), by the reduction of excessive ROS (oxidative stress) and through the down regulation of ERK (key growth factor needed for cellular division).

“Effects of molecular hydrogen have been observed essentially in all the tissues and disease states including the brain, spinal cord, eye, ear, lung, heart, liver, kidney, pancreas, intestine, blood vessel, muscle, cartilage, metabolism, perinatal disorders, and inflammation/allergy.

Among them, marked effects are observed in ischemia/reperfusion disorders as well as in inflammatory disorders. It is interesting to note, however, that only three papers addressed effects on cancers. First, molecular hydrogen caused growth inhibition of human tongue carcinoma cells HSC-4 and human fibrosarcoma cells HT-1080 but did not compromise growth of normal human tongue epithelial-like cells DOK. Second, hydrogen suppressed the expression of vascular endothelial growth factor (VEGF), a key mediator of tumor angiogenesis, in human lung adenocarcinoma cells A549, which was mediated by downregulation of extracellular signal-regulated kinase (ERK). Third, hydrogen protected BALB/c mice from developing radiation-induced thymic lymphoma. Elimination of radical oxygen species by hydrogen should reduce a probability of introducing somatic mutations.” (8)

H2 has also been shown to reduce the excessive expressions of MMP genes (MMP proteins are in involved in multiple functions in cells, including cell proliferation, cartilage synthesis, apoptosis, angiogenesis, etc). It has been shown that cancerous cells have a higher expression of MMP genes leading to tumor invasion and tumor angiogenesis. H2 has been shown to reduce tumor invasion and tumor growth and because of this effect, H2 has been shown to have anti-tumor effects (8, 9).

“ERW [hydrogen water] causes telomere shortening in cancer cells and suppresses tumor angiogenesis by scavenging intracellular ROS and suppressing the gene expression and secretion of vascular endothelial growth factor. In addition, ERW induces apoptosis together with glutathione in human leukemia HL60 cells (Tsai et al. 2009a, b).” (11, 12)

“Treatment with both H2 waters (HHW and NHW) increased the expression of p-AMPK, AIF and Caspase 3 (cell apoptosis pathways) in colon 26 cells. Thus, H2 water resulted in cell apoptosis mediated by the AMPK pathway in colon 26 cells.” (13)

H2 may protect healthy tissue/cells from anticancer drugs and has been shown through medical studies that molecular hydrogen has a protective effect against chemotherapy drugs. Hydrogen has potential for improving the quality of life of patients during chemotherapy by efficiently mitigating the side effects of cisplatin.” (9)

Molecular hydrogen may have the potential to retard the development of some cancers. It was demonstrated that molecular hydrogen may protect and retard the development of thymic lymphoma in mice.

“The radiation-induced thymic lymphoma rate in the H2 (+) group was significantly lower than in the control group and H2 treatment significantly increased the latency of lymphoma development after the split-dose irradiation. These data indicated that H2 protects mice from radiation-induced thymic lymphoma in BALB/c mice.” (20)


I have personally observed a patient recover from near death with reoccurring breast cancer years after surgery, which had spread to her lymph system and then on to her brain. She wrote, “After a few visits to the ER, I found out I had a tumor on the cerebellum that was blocking fluid from draining down the spinal cord. On the base of my skull is a 2cm tumor. It’s making me vomit and walk sideways. I could not keep food or water down and I began walking like a crab,” she reported on the 9th of September. Understanding the severity of the situation I took a long shot and recommended not only hydrogen water but also a hydrogen inhaler. On the 26th of September, using the full Natural Allopathic protocol with incredible dedication to slowing her breathing down, using the Frolov breathing device, she wrote, and “So I walk now! Eat like crazy, gained 10 pounds, and feel better every day. Don’t drive yet but I walk in the neighborhood. Not far. Have not thrown up. Feel stronger ever day! Just hope to keep going!” I published her initial success in my essay New Advances in Gas Therapy and will soon report her full testimony. My readers will have to excuse my reporting on this case as it is happening but it is too exciting and too important.

Two years ago, before I even had heard about the miracles of molecular hydrogen I got a letter from another patient also on the verge of death. This patient reported, “Significant metastases in my spine, hips, ribs, neck, lymph nodes – and my PSA was 2,080,” I entitled my essay, ‘One foot in the grave when I found Dr. Sircus. He wrote, “I wanted to contact Dr. Sircus when I was completely healed and tell him my story. My PSA is now 2.1. If his protocol plus my work and the grace of God could get me off my death bed, and dancing all night with my family well maybe people should consider this wonderful protocol and try it.” I share these cases to show what is possible if people work hard enough doing the right things. Both of these patients showed extraordinary will successfully and willfully doing the most difficult part of my protocol, which is breathing retraining. Another famous case written up in my bestselling book Sodium Bicarbonate was Vernon Johnston, who breathed his way back to life by using sodium bicarbonate perfectly while breathing consciously four hours a day.

Hydrogen is new in medical science and even newer in relationship to the treatment of cancer. Hydrogen is safe, easily administered, a potent antioxidant, and gets everywhere it is needed because of its small size. I do not know of anyone reporting anything close to a case like this. It should be everyone’s hope that she makes it and recovers fully though a relapse is always possible. There is nothing to lose administering high dosages of hydrogen and everything to gain for cancer patients.

According to the National Cancer Institute considerable laboratory, evidence from chemical, cell culture, and animal studies indicates that antioxidants may slow or possibly prevent the development of cancer. Antioxidants are nutrients (vitamins and minerals) as well as enzymes (proteins in your body that assist in chemical reactions). Hydrogen just happens to be the smallest and as it does its work it promotes full hydration.

[1] Cancer Lett. 2012 Dec 31; 327(0): 48–60. Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury
[2] International Journal of Cell Biology. Volume 2012 (2012), Article ID 683897, 16 pages
Electromagnetic Fields, Oxidative Stress, and Neurodegeneration
[3] Collateral Damage in Cancer Chemotherapy: Oxidative Stress in Nontargeted Tissues. DOI: 10.1124/mi.7.3.6 · Source: PubMed
[4] Integr Cancer Ther. 2004 Dec;3(4):294-300. Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness.
[5] Drug Metabolism and Oxidative Stress: Cellular Mechanism and New Therapeutic Insights
Sharmistha Banerjee, Jyotirmoy Ghosh and Parames C Sil. Division of Molecular Medicine
[6] Cancer and Oxidative Stress JMAJ 44(12): 535–539, 2001
[7] Med Gas Res. 2011; 1: 18. Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide
[8] Oxid Med Cell Longev. 2012; 2012: 353152. Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases
[9] Med Gas Res. 2011; 1: 18. Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide
[10] Expression of Metalloproteinases MMP-2 and MMP-9 in Sentinel Lymph Node and Serum of Patients with Metastatic and Non-Metastatic Breast Cancer
[11] Cytotechnology. 2012 May; 64(3): 357–371. Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells
[12] PeerJ. 2015; 3: e859. Hydrogen–water enhances 5-fluorouracil-induced inhibition of colon cancer
[13] Cancer Chemotherapy and Pharmacology. September 2009, 64:753. Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice.
[14] Int J Biol Sci. 2011; 7(3): 297–300. Hydrogen Protects Mice from Radiation Induced Thymic Lymphoma in BALB/c Mice

Respectfully submitted by:
*Licensed Psychologist
*Certified  Psychoanalyst
*Stone Carrier Medicine Woman, Native American Traditional Organization

This Holiday Season—for the whole month of December—La Casa is offering a special on gift certificates. Buy an hour-long therapy, and receive 25% off your second purchase toward any other treatment.

Also for the month of December, we are offering a special on any of our 10 boutique colonics, normally $155, for the cost of our Classic Colonic: $115. If you have not already tried one of our specialty colonics with specific digestive (and whole body) effects, some not available anywhere else in the world, take advantage of our holiday special.


(our most systemically effective colonic)

This is a colonic like none other, and La Casa is the only place in the entire world you can have it. We augment the colon cleansing with Pulsed Electric Magnetic Field therapy (PEMF). This is a painless enhancement of the cleansing process. In fact, it will feel quite wonderful. As you are expelling your discharge, we will send gentle pulsed magnetic energy into your abdomen from our PEMF machine, an FDA medically approved device. It’s a 1-2 punch: you get the benefits of the colonic with all the added benefits of the therapeutic effect from the PEMF (which are systemic).


(our most oxygenating colonic)

While you are having the benefit of your colon cleansing, you will be lying atop the Bio-Mat. Combining the healing effects of hefty emissions of both negative ions and far-infrared waves, your body will respond with enthusiasm. The Bio-Mat oxygenates the whole body as well as increasing circulation. It also alkalizes the body and strengthens the immune system by stimulating the production of white blood cells and killer T-cells. Most relevantly for the Bio-Colonic, the Bio-Mat dissolves hidden toxins, making them available for elimination through the cleansing action of the colon hydrotherapy.


(our most immune-

enhancing colonic)

This colonic is performed with essential oils as well as a castor oil pack placed with a hot compress on the abdomen.  Don’t underestimate the power of the little castor bean, from which castor oil is extracted.Castor oilis an anti-toxin that impacts on the lymphatic system and enhances immunological function. The oil specifically strengthens the Peyer’s Patches, which are tiny patches of lymphatic tissue in the mucosal surface of the small intestine, and are an important element of the body’s immune system. Castor oil increases the number of T-11 cells with a concomitant increase in the number of total lymphocytes. This represents a general boost in the body’s specific defense status, since lymphocytes actively defend the health of the body by forming antibodies against pathogens and their toxins. Castor oil is both anti-inflammatory and antimicrobial (antibacterial, antiviral, and antifungal), and there is also research indicating it kills cancer cells as well. The oil’s benefits can be derived by topical application (in fact, skin absorption is even more effective than swallowing it), and the application of heat augments the effect. When castor oil is absorbed through your skin, the lymphocyte count increase speeds up the removal of toxins from your tissues, which, in turn, promotes healing.


(our most soothing colonic)

This colonic uses the Japanese technology of Onnetsu. The healing power of Far-infrared energy is sent to strategic places on the abdomen. Differences in temperature can be discerned, and these differences detect the location of unhealthy areas deep within the body, guiding the therapist to concentrate on these areas. As well, the penetration of light (8-15 microns) and heat (130* F) emanating from the Onnetsu device delivers therapeutic efficacy by increasing the flow of fluid and energy systems in the body: blood, lymph and Chi.


(our most electrolyte-replenishing colonic)

This colonic implants into the colon 24 vials of Quinton Sea Plasma. In 1897 Frenchman Rene Quinton discovered the remarkable healing ability of biologically active sea water from nutrient-rich plankton blooms. We call it “marine plasma” because the ratio of minerals and trace minerals of blood, comprising the biochemical and electrolytic composition of blood, is almost identical to sea water. Health benefits are extraordinary, as the treatment regulates our internal ocean (our tidal body), developed initially from amniotic fluid, and then translating into our blood, our lymphatic and extra-cellular fluids. And because the ocean has 20 billion genes, the marine plasma has the ability to inform our own genetic material and potential.

Click HERE to donate to La Casa Puerto Rico, in our rebuilding efforts.

Donations to

La Casa Spa & Wellness Puerto Rico are tax deductible.

La Casa Spa & Wellness Puerto Rico
is registered as a not-for-profit corporation.

(Corporación Doméstica Sin Fines de Lucro (not-for profit): registration number 400094)

Jane spoke at the Navel Health Expo in New York City at the end of October. The title of her talk was “Disease is Not a Mistake” and can be viewed in full by clicking the image below.

Jane is pleased to announce that she’ll be speaking at the Annie Appleseed Project’s annual conference.

The 12th Annual Complementary & Alternative Cancer Therapies conference will be held March 1-3, 2018, in West Palm Beach, FL.

Conference details can be found in full HERE.

Jane was recently interviewed by Jeremy Jones for his podcast. 

You can listen to it by clicking HERE.

Big ideas discussed include:

  • Knowing “No” — why “no” is the most important word; how “no” creates a separate self
  • The separation between mother and child is a life-long endeavor, fraught with pain, difficulty, and conflict (as well as glorious joy). It must be done carefully and deliberately in order for both mother and child to thrive, both together as well as individually.
  • Language is the biggest superpower we humans have.

For a complete archive of all previous issues of Musings From 20th Street, simply click HERE!

Jane’s latest book is out now through Free Association Books, and available through AMAZON!

Jane speaks around the country about holistic health and the true origins of disease.

If you are interested in  interviewing her for your podcast or radio show, or if you would like to book her to speak at an event, please get in touch:




La Casa has a brand new brochure out, introducing new therapies as well as innovative packages at significant price-saving costs.

Stop by the Spa & Wellness Center soon to pick up your copy and find out which of our healing and nourishing therapies is right for you.

La Casa Spa and Wellness Center was created out of the experience one woman had with her mother. Long before holistic medicine became widely known, Dr. Jane Goldberg spent the 1970s seeking alternative cancer therapies for her mother, who had been diagnosed with terminal bone cancer. Following sound principles of holistic health, Jane’s mother was able to reverse her cancer condition entirely, moving from her wheelchair to joyfully playing tennis again. This experience inspired Jane to specialize in her psychoanalytic practice to work with cancer patients, and to fulfill the need for a holistic healing center in NYC. Jane and La Casa invite you to partake of the restorative and profoundly cleansing therapies that have brought La Casa world-wide recognition.

Legal Disclaimer
Information provided is for informational purposes only and is not a substitute for professional medical advice. No health claims for these products or therapies have been evaluated by the United States Food and Drug Administration (FDA), nor has the FDA nor any other medical authority approved these products pr therapies to diagnose, cure, or prevent disease. Since every person is unique, we highly recommend you to consult with your licensed health care practitioner about the use of products or therapies discussed here as it relates to your particular situation.