- 1979- approved for stimulating bone growth and non-union bone fractures
- 1987- approved for treating post-operative edema and pain
- 2004- approved as an adjunct to cervical fusion surgery
- 2008- approved for treatment in depression
- 2011- approved for treatment of brain cancer
- 2013- approved for treatment of migraine headaches
- 2016- approved for urinary incontinence and muscle stimulation